Abstract:
OBJECTIVE: Antibiotic resistance is increasing among organisms that commonly cause wound infections. Therefore, it becomes increasingly desirable to prevent wound infections as systemic antibiotic treatment of established wound infections becomes more difficult, more expensive, and potentially more toxic. The ability to incorporate antimicrobial compounds into modern wound dressings provides an opportunity to prevent wound infections without the risk of systemic toxicity, thus diminishing morbidity, mortality, and cost to the healthcare system.
DESIGN: In these studies, the authors tested 16 antimicrobial agents in a unique composite wound dressing (TheraGauze; Soluble Systems, LLC, Newport News, Virginia) against clinical methicillin-resistant Staphylococcus aureus isolates and Gram-negative organisms commonly associated with wound infections and antibiotic resistance. Disk diffusion susceptibility testing is used to quantify antimicrobial activity.
RESULTS: Broad-spectrum antimicrobial activity was found for the following agents in the composite wound dressing: hydrogen peroxide, tobramycin, chlorhexidine digluconate, chlorhexidine gluconate, levofloxacin, and silver.
CONCLUSION: These studies suggest that potent local antibacterial activity can be achieved with several antimicrobials in this wound dressing.
(C) 2010 Lippincott Williams & Wilkins, Inc.
From the International Wound Journal…
The aim of this study was to observe both the clinical signs and symptoms of wounds at risk of infection, that is critically colonised (biofilm infected) and antimicrobial-performance of an ionic silver alginate/carboxymethylcellulose (SACMC) dressing, in comparison with a non silver calcium alginate fibre (AF) dressing, on chronic venous leg and pressure ulcers. Thirty-six [...]
From the International Wound Journal…
ABSTRACT
The physical capacity of negative pressure wound therapy (NPWT) dressing on the bacterial growth in an in vitro wound model was investigated. Standardised wounds were contaminated with a clinical Staphylococcus aureus strain and incubated at 35°C for 6 hours. Four wounds were treated with continuous negative pressure (125 mmHg) and four [...]
There has been a resurgence of silver dressings in wound care in recent years due to the antimicrobial activity of silver, its safety and a lack of resistance. Accordingly, this author discusses silver dressing selection, shares insights on nanocrystalline silver and assesses the current literature on silver in wound care.
From Advances in Skin and Wound Care…
Abstract
PURPOSE: To enhance the clinician’s knowledge about the relationship between increased periwound skin temperature and local wound infection in patients with chronic leg ulcers.
TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care.
OBJECTIVE: After participating in this educational activity, [...]
From Wound Repair and Regeneration…
ABSTRACT
Previous experimental studies to assess the contribution of blood-borne circulating (BBC) cells to cutaneous wound healing have relied on discontinuous pulsing of labeled BBC elements or bone marrow transplant protocols. Such approaches do not allow the examination of stable BBC cells that have matured in a physiologically normal host. We have [...]
